On the interaction of 6-fluoro-3-hydroxypyrazine-2-carboxamide (favipiravir) with arynes

V. Вадимовна Zavyalova, N. Валерьевна Slovesnova, V. Евгеньевна Petrova, A. Юрьевич Petrov, S. Евгеньевна Vatolina, A. Петрович Krinochkin, I. Сергеевич Kovalev, O. Владимировна Shabunina, D. Сергеевич Kopchuk, G. Васильевич Zyryanov

Abstract


6-Fluoro-3-hydroxypyrazine-2-carboxamide (favipiravir) was one of the drugs recommended for the treatment of COVID-19. As with other drugs, the issue of disposal of expired medicinal substances is relevant for favipiravir. In the present study we investigated a method for possible chemical utilization of favipiravir by its reaction with arynes (1,2-dehydrobenzenes) to form isoquinolines, usable in practice.

Keywords


COVID-19; 6-fluoro-3-hydroxypyrazine-2-carboxamide; favipiravir; utilization; arynes; 3-fluoroisoquinoline-1-carboxamide

Refbacks

  • There are currently no refbacks.