A new method for preparation of substituted 2-aminobuta-1,3-diene-1,1,3-tricarbonitriles

A. R. Chikava, A. A. Russkikh, A. A. Amirkhanyan, A. A. Dolganov, D. S. Buryi, A. V. Bespalov, N. A. Ryzhkova, V. V. Dotsenko, S. G. Krivokolysko

Abstract


The reaction of the potassium salt of malononitrile dimer with aromatic aldehydes in aqueous acetic acid at 40-50 °C leads to formation of 3-aryl-2-aminobuta-1,3-diene-1,1,3-tricarbonitriles. The catalyst required for Knoevenagel condensation (potassium acetate) is generated in situ in the reaction medium. The 3-aryl-2-aminobuta-1,3-diene-1,1,3-tricarbonitriles have been prepared in 71-95% yields and can be used as initial reagents for heterocyclic synthesis.

Keywords


malonononitrile; potassium salt of malonononitrile dimer; Knoevenagel condensation; enaminonitriles

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