RESEARCH OF 2-THIOURACIL DERIVATIVES BY X-RAY METHOD
Keywords:
2-prenylthio-6-trifluoromethyl-4(3H)-pyrimidinone, cis-2-(3-chloroallyl)thio-6-trifluoromethyl-4(3H)-pyrimidinone, 2-allylthio-6-methyl-4(3H)-pyrimidinone, alkylation, propargyl bromide, tautomerism, molecular structure, X-ray analysisAbstract
2-Propargylthio-6-methyl-5-ethyl-4(3H)-pyrimidinone has been synthesized by alkylation of S-sodium salt of 6-methyl-5-ethyl-2-thiouracil with propargyl bromide. It has been found by X-ray method that S-derivatives of 2-thiouracil are in the tautomeric form with the proton at the nitrogen atom N3. The substitute at the sulfur atom is within the plane of pyrimidine ring at the angle 59–84°. The 2-alkylthio-4(3H)-pyrimidinones molecules are combined in dimers with formation of two intermolecular hydrogen bonds.
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