Synthesis and possibilities of practical application of condensed 1,3,5-triazinones(thiones)

Abstract

Many 1,3,5-triazines ang their derivatives have high biological activity and are used as antibacterial, antifungal, antiviral, antituberculosis, antibacterial, antitumor, and anticancer agents. Furthermore, 1,3,5-triazine derivatives include pesticides and herbicides. The presence of two pharmacophore fragments in one molecule can lead to increased biological activity, and the similarity of condensed systems containing 1,3,5-triazine to purine systems significantly increases scientists interest in the creation of new heterocondensed 1,3,5-triazine derivatives and the investigation of their biological activity. Due to the high interest and the emerging need to systematize and summarize the available literature data on the named compounds, this paper analyzes the literature data published primarily from 2003 to 2025. The methods of synthesis and the possibilities of practical application of condensed systems with 1,3,5-triazinone and/or 1,3,5-triazinethione are described.