CLINICAL EVIDENCE FOR THE EFFECTIVENESS OF OLEOPREN NEYRO DIETARY SUPPLEMENT IN PREVENTION AND COMPREHENSIVE TREATMENT OF DYSCIRCULATORY ENCEPHALOPATHY OF VASCULAR GENESIS
Keywords:
dietary supplement, nutrition correction, diet, effectiveness, functional orientation, dyscirculatory encephalopathy, preventive treatment, comprehensive treatment, polyprenols, dolichol phos-phate cycle.Abstract
Clinical trials of effectiveness and functional orientation of a special product – Oleopren Neyro dietary supplement – on a representative group of patients with dyscirculatory encephalopathy of vascular genesis of stages I – II are carried out. The product has been included in the patients’ diet along with basic therapy in a dose of one capsule twice a day during 10 days. Indexes of clinical symptoms and signs such as: general physical and mental state of the patients, headache, process of memorizing and recalling reads, initiative, attentiveness and concentration, emotional-volitional sphere, muscular tone, hypertensive syndrome, electroencephalogram (EEG), rheoencephalogram are studied along with the indexes of life quality: energy level, sensation of pain, emotional condition, sleep, social isolation, physical activity. As a result of the therapy, distinct positive dynamics of clinical disease is registered: general condition of 95 % of patients has improved. After treatment with the use of nutrition factor, short-term memory capacity has increased, the majority of patients can correctly repeat 10 words; average time for completing a task for attention concentration has decreased from 61,1 seconds before the beginning of the treatment to 43,5 seconds in the control group and 40,6 in the group of patients with dyscirculatory encephalopathy who have been taking Oleopren Neyro, on completing the therapy (Р < 0,05). The obtained research results give grounds for recommending the dietary supplement as an effective agent for enhancing body resistance to adverse effect of the environment, stressful situations, psychoemotional and physical exertions. Test product can be used in comprehensive treatment, and in order to prevent encephalopathy of different nature (residual, vascular, post-traumatic, toxical). Possible influence of nutrition factor on metabolism correction, connected with functional disorder of dolichol phosphate cycle at the cell membrane level, increased removal of dolichols from the body and promotion of their deficiency, is studied. Polypropenols as a part of dietary supplement composition hold key positions in the dolichol phosphate cycle and provide biosynthesis of glycoproteins and glucoaminoglukans, glycosylation of membrane proteins, preventing their proteolysis.
References
Австриевских, А.Н. Продукты здорового питания: новые технологии, обеспечение качества, эффективность применения / А.Н. Австриевских, А.А. Вековцев, В.М. Позняковский. – Новосибирск: Сиб. унив. изд-во, 2005. – 416 с.
Герасименко, Н.Ф. Здоровое питание и его роль в обеспечение качества жизни / Н.Ф. Герасименко, В.М. Позняковский, Н.Г. Челнакова // Технологии пищевой и перера-батывающей промышленности АПК – продукты здорового питания. – 2016. – № 4 (12). – С. 52–57.
Здоровье России: атлас / под ред. Л. А. Бокерия. – 8-е изд. – М.:НЦССХ им. А.Н. Бакулева РАМН, 2012. – 408 с.
Позняковский, В.М. Пищевые ингредиенты и биологически активные добавки / В.М. Позняковский, О.В. Чугунова, М.Ю. Тамова. – М.: ИНФРА-М, 2017. – 143с.
Политика здорового питания. Федеральный и региональный уровни / В.И. По-кровский, Г.А. Романенко, В.А. Княжев и др. – Новосибирск: Сиб. унив. изд-во, 2002. – 344 с.
Спиричев, В.Б. Обогащение пищевых продуктов витаминами и минеральными веществами. Наука и технология. / В.Б. Спиричев, Л.Н. Шатнюк, В.М. Позняковский; под общ. ред. В.Б. Спиричева. – 2-е изд. – Новосибирск: Сиб. унив. изд-во, 2005. – 548 с.
Тутельян, В.А. Микронутриенты в питании здорового и больного человека (Справочное руководство по витаминам и минеральным веществам) / В.А. Тутельян, В.Б. Спиричев, Б.П.Суханов, В.А.Кудашева. – М.: Колос, 2002. – 424 с.
Тутельян, В.А. Современное состояние и перспективы развития науки о питании / В.А. Тутельян, В.М. Позняковский // Современные приоритеты питания, пище-вой промышленности и торговли: сб. научн. трудов, посвященных юбилею кафедры биотехнологии, товароведения и управления качеством / под общ. ред. В.М. Позняковского. – М.; Кемерово: Издательское объединение «Российские университеты»: «АСТШ: Кузбассвузиздат», 2006. – С. 5–10.
Тутельян, В.А. Научные основы здорового питания / В.А. Тутельян, А.И. Вялков, А.Н. Разумов и др. – М.: Издательский дом «Панорама», 2010. – 816 с.
Челнакова, Н.Г. Питание и здоровье современного человека: монография / Н.Г. Челнакова, В.М. Позняковский. – Ростов-на-Дону: Изд-во «Старые русские», 2015. –224 с.
Eggens, I. Studies of the polyisopre-noid composition in hepatocellular carcino-mas and its correlation with their differentia-tion / I. Eggens, P.G. Elmberger // APMIS 98. – 1990. – № 6. – Р. 535–542.
Bergamini, E. Ageing and oxidative stress: a role for dolichol in the antioxidant machinery of cell membranes? / E. Bergamini, R. Bizzarri, G. Cavallini // J. Alzheimer's Dis. – 2006. – № 6. – Р. 129–135.
Chojnacki, T. The uptake of dietary polyprenols and their modification to active dolichols by the rat liver / T. Chojnacki, G.J. Dallner // J. Biol. Chem. – 1983. V. 258. – P. 916–922.
Sweiezewska, E. Polyisoprenoids: structure, biosynthesis and function / E. Sweiezewska, W. Danikiewiez // Progress in Lipid Research. – 2005. – V. 44. – P. 235–250.
Safatov, A.S. A prototype prophylactic anti-influenza preparation in aerosol form on the basis of Abies sibirica polyprenols / A.S. Safatov, A.N. Boldyrev, L.E. Bulychev //. J. Aerosol. Med. – 2005. V. 18 (1). – P. 55–62.
Kozlov, V.V. Separation of polyprenyl phosphate oligomerhomologues by reserved-phase / V.V.Kozlov, L.L. Danilov // Analytical science. – 2012. – V. 28. – P. 1021–2023.
Kazimierczak, B. On the specific pat-tern of long chain polyprenols in green nee-dles of PinusmugoTurra / B. Kazimierczak, J. Hertel, E. Swiezewska // Acta Biochim. – 1997. – V. 44 (4). – P. 803–808.
Rezankam T. Chromatography of long chain alcohols (polyprenols) from animal and plant sources / T. Rezanka, J. Vortuba // J. Chromatogr. – 2001. – V. 936 (1–2). – P. 95–110.
Roschin, V.I. Chemical composition of lipid fraction of green pine and spruce needles. In edition Study and application of therapeutic-prophylactic medications based on natural biologically active compounds / V.I. Roschin. –
SPb.: Eskulap, 2000. – P. 114–116.
Wojtas, M. Polyisoprenoid alcohols from the mushroom Lentinus edodes / M. Wojtas // Chemistry and Physics of Lipids. – 2004. – V. 130 (2). – P. 109–115.
Walinska K. Comprasion of the influ-ence of the polyprenol structure on model membranes // Desalination. – 2004. – V. 163. – P. 239–245.
