BIOLOGICAL ACTIVE SUBSTANCES IN COMPENSATION OF HYPERGLYCEMIA MANIFESTATIONS
Keywords:
diabetes, biologically active substances, spice plants, functional foods, adaptogensAbstract
Metabolic disorders such as hyperglycemia and hypercholesterolemia became a big threat to the health and life of a modern person. Such factors as aging, obesity, reduced physical activity, population growth, and urbanization can gradually lead to a steady increase in the number of people with diabetes. According to IDF Diabetes Atlas, the prevalence of diabetes is expected to increase by 2035 from 382 to 471 million people. In addition to life-threatening conditions such as diabetic ketoacidosis, hyper- and hypoglycemic coma, diabetes mellitus is a risk factor for myocardial infarction, ischemic stroke, and other vascular disorders. Therefore, the search for new solutions to these problems is one of the main tasks of health care worldwide. In these conditions, researchers turn their attention to identifying natural substances that can cope with these metabolic disorders. The use of various extracts and infusions based on plant materials to compensate and prevent diabetes mellitus has been known since ancient times. Today, the pharmaceutical and food industries are developing a wide range of dietary supplements and functional foods to maintain a high quality of life and to adapt people with different manifestations of hyperglycemia. The action of the components of spice plants is based on the mechanisms of protection and restoration of pancreatic β-cells in the Langerhans islets, which allows to increase the secretion of insulin and at the same time protect the β-cell from destruction. This article is devoted to the review of the basics of spice plants and the biologically active components contained in them, allowing to compensate for hyperglycemic manifestations.References
Al-Suhaimi E.A., Al-Riziza N.A., & Al-Essa R.A. (2011). Physiological and therapeutical roles of ginger and turmeric on endocrine functions. The American Journal of Chinese Medicine, 39, 215–231. DOI: 10.1142/S0192415X11008762
Ali Z., Ferreira D., Carvalho P., Avery M.A., Khan I.A. Nigellidine-4-O-sulfite, the first sulfated indazole-type alkaloid from the seeds of Nigella sativa. J Nat Prod 2008; 71(6): 1111-1112. DOI: 10.1021/np800172x
Amr A.R., & Maysa M.E. (2010). Antiulcer effect of cinnamon and chamomile aqueous extracts in rat models. The Journal of American Science, 6, 209–216.
Bamosa A.O., Kaatabi H., Lebda F.M., Elq A.M., & Al-Sultanb A. (2010). Effect of Nigella Sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian Journal of Physiology and Pharmacology, 54, 344–354.
Burits M., Bucar F. Antioxidant activity of Nigella sativa essential oil. Phytother Res 2000; 14(5): 323–328. DOI: 10.1002/1099-1573(200008)14:5<323::AID-PTR621>3.0.CO;2-Q
Choudhury H., Pandey M., Hua Ch., Cheah Shi Mun, Jing J.K., Kong L., Ern L.Y., Ash-raf N.A. i Kit S.W. (2018) An update on natural compounds in the remedy of diabetes mellitus: A systematic review. Journal of Traditional and Complementary Medicine 8, 361–376. DOI: 10.1016/j.jtcme.2017.08.012
El-Ghorab A.H., El-Massry K.F., Marx F., Fadel H.M. Antioxidant activity of Egyptian Eucalyptus camaldulensis var. brevirotsris leaf extracts. Food 2003; 47(1): 41–45. DOI: 10.1002/food.200390009
Elosta A., Ghous T., & Ahmed N. (2012). Natural products as anti-glycation agents: Possible therapeutic potential for diabetic complications. Current Diabetes Review, 8, 92–108. DOI: 10.2174/157339912799424528
Faqih A.M., & Al-Nawaiseh F.Y. (2006). The immediate glycemic response to four herbal teas in healthy adults. Jordan Medical Journal, 40, 266–275.
Gali-Muhtasib H., El-Najjar N., Schneider-Stock R. The medicinal potential of black seed (Nigella sativa) and its components. Adv Phytomed 2006; 2: 133–153. DOI: 10.1016/S1572-557X(05)02008-8
Gray A.M., & Flatt P.R. (1999). Insulin releasing and insulin-like activity of the traditional antidiabetic plant Coriandrum sativum (coriander). British Journal of Nutrition, 81, 203–209. DOI: 10.1017/S0007114599000392
Hameed I., Dastagir G., Hussain F. Nutritional and elemental analyses of some selected medicinal plants of the family Polygonaceae. Pak J Bot 2008; 40(6): 2493–2502.
Hussein M.R., Abu-Dief E.E., Abd El-Reheem M.H., Abd-Elrahman A. Ultrastructural evaluation of the radioprotective ef- fects of melatonin 237 against X-rayinduced skin damage in Albino rats. Int J Clin Exp Pathol 2005; 86(1): 45–55. DOI: 10.1111/j.0959-9673.2005.00412.x
Imparl-Radosevich J., Deas S., Polansky M.M., Baedke D.A., Ingebritsen T.S., Ander-son R.A., & Graves D.J. (1998). Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: Implications for cinnamon regulations of insulin signalling. Hormone Research, 50, 177–182. DOI: 10.1159/000023270
Jagtap A G., & Patil P.B. (2010). Antihyperglycemic activity and inhibition of advanced glycation end product formation by Cuminum cyminum in streptozotocin induced diabetic rats. Food and Chemical Toxicology, 48, 2030–2036. DOI: 10.1016/j.fct.2010.04.048
Jayaprakasha G.K., Ohnishi-Kameyama M., Ono H., Yoshida M., & Jaganmohan R.L. (2006). Phenolic constituents in the fruits of Cinnamomum zeylanicum and their antioxidant activity. Journal of Agricultural and Food Chemistry, 54, 1672–1679. DOI: 10.1021/jf052736r
Kaefer C.M., & Milner J.A. (2008). The role of herbs and spices in cancer prevention. The Journal of Nutritional Biochemistry, 19, 347–361. DOI: 10.1016/j.jnutbio.2007.11.003
Kooti W., Noohi Z.H., Sharafi-Ahvazi N., Asadi-Samani M., Ashtary- Larkye D. Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa). Chin J Nat Med 2016; 14(10): 732–745. DOI: 10.1016/S1875-5364(16)30088-7
Kurokawa M., Kumeda C.A., Yamamura J., Kamiyama T., & Shiraki K. (1998). Antipy-retic activity of cinnamyl derivatives and related compounds in influenza virusinfected mice. European Journal of Pharmacology, 348, 45–51. DOI: 10.1016/S0014-2999(98)00121-6
Lee H. (2005). Cuminaldehyde: Aldose reductase and a-glucosidase inhibitor derived from Cuminum cyminum L. seeds. Journal of Agriculture and Food Chemistry, 53, 2446–2450. DOI: 10.1021/jf048451g
Li Y., Tran V.H., Duke C.C., & Roufogalis B.D. (2012b). Preventive and protective properties of Zingiber officinale (Ginger) in diabetes mellitus, diabetic complications, and associated lipid and other metabolic disorders: A brief review. Evidence-Based Complementary and Alternative Medicine, 2012, 516870. DOI: 10.1155/2012/516870
Neelakantan N., Narayanan M., Souza R.J., & Dam R.M. (2014). Effect of fenugreek (Trigonella foenumgraecum L.) intake on glycemia: A metaanalysis of clinical trials. Nutrition Journal, 13, 7. DOI: 10.1186/1475-2891-13-7
Neeraja A., & Rajyalakshmi P. (1996). Hypoglycemic effect of processed fenugreek seeds in humans. Journal of Food Science and Technology, 33, 427–430.
Sharma R.D. (1986). Effect of fenugreek seeds and leaves on blood glucose and serum insulin responses in human subjects. Nutrition Research, 6, 1353–1364. DOI: 10.1016/S0271-5317(86)80020-3
Singh G., Maurya S., DeLampasona M.P., & Catalan C.A. (2007). A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents. Food and Chemical Toxicology, 45, 1650–1661. DOI: 10.1016/j.fct.2007.02.031
Srichamroen A., Thomson A.B.R., Field C.J., & Basu T.K. (2009). In vitro intestinal glucose uptake is inhibited by galactomannan from Canadian fenugreek seed (Trigonella foenum-graecum L.) in genetically lean and obese rats. Nutrition Research, 29, 49–54. DOI: 10.1016/j.nutres.2008.11.002
Rajeshwari C.U., Abirami M., & Andallu B. (2011). In vitro and in vivo antioxidant potential of aniseeds (Pimpinella anisum). Asian Journal of Experimental Biological Sciences, 2, 80–89.
Tung Y.T., Chua M.T., Wang S.Y., & Chang S.T. (2008). Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs. Bioresource Technology, 99, 3908–3913. DOI: 10.1016/j.biortech.2007.07.050.
